PTPRZ1 and central nervous system cancer: Bcan encodes a member of the lectican family of chondroitin sulfate proteoglycans, which are usually highly expressed in gliomas and a subtype of the OPCs, and may promote the growth and cell motility of brain tumor cells (74); Cntn1 encodes the cell adhesion molecule contactin 1, which has been proven to bind to its ligand PTPRZ1.