High SDI was positively correlated with tumor infiltration of CD4+ CD69+ and CD4+ PD1+ T-cells at week 3, and CD4+ ki67+ T-cells at week 5 (P = 0.004, Q = 0.14; P = 0.036, Q = 0.21; P = 0.004, Q = 0.07, respectively; Table 3). Here, CD4 is linked to neoplasm.