In contrast, there is a slightly positive correlation between the expression levels of CD274 and PDCD1LG2 genes, that encodes PD-L1 and PD-L2 respectively, with the expression levels of PDCD1 and INFG, and the percentage of CD8+ T-cells in ccRCC tumors (Fig. 5E). This evidence concerns the gene CD8A and nonpapillary renal cell carcinoma.