Although Cluster (\documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$CD8< CD4\approx M\Phi $$\end{document}CD8<CD4≈MΦ) includes a high number of patients with lower grade and without tumor in the last follow up time, tumors in this cluster have lower levels of INFG and PDCD1, therefore patients in this cluster may not be a good candidate for anti PD-1 therapies. This evidence concerns the gene CD8A and neoplasm.