CD4 and melanoma: Genes in M7 sub-modules were expressed in distinct cell types, predominantly melanoma cells (expressed in M401, M402, M110, M639, and M642), M1-macrophages (expressed in M400, M401, and M642), B-cells (expressed in M111), CD8+ T cells (expressed in M399, M401, M402, and M403) and CD4+ T cells (expressed in M399, M401, and M402, Supplementary Fig. 4C).