Given the close interaction between STAT1 and MYO1F (Pearson ρ = 0.32, p = 9.88E − 4), these observations also support the regulatory roles of MYO1F in M1-polarization and STAT1 activation in macrophages, leading to increased IFN-γ secretion in the melanoma microenvironment. Here, IFNG is linked to melanoma.