CD274 and hepatocellular carcinoma: PD-L1 expression on macrophages, rather than on tumor cells, was positively correlated with patients’ overall survival (OS) and might be used as an independent prognostic factor based on a cohort study of 453 HCC patients.87 Surprisingly, PD-L1+ TAM-enriched tumors exhibited an activated immune status, with high levels of CD8+ T cell infiltration and immune-related gene expression, which indicates that a substantial proportion of tumor might be a amenable to ICI therapy.87–89