The constitutive expression of Fcγ receptor (FcγR) on monocytes/macrophages plays a crucial role in the antibody-dependent phagocytosis (ADCP) of tumor cells.105 However, it is worth noting that TAMs may have a significant impact on the pharmacokinetics and efficacy of ICI via Fc-FcγR binding. The gene discussed is FCGR2A; the disease is neoplasm.