ITGAM and neoplasm: Anti-CD11b antibody-mediated depletion of myeloid cells showed a synergistic effect along with the vaccine by further prolonging the survival of tumor-bearing mice, although no significant reduction in tumor burden was observed.128 Injection of tumor lysate-pulsed DC also prolonged the survival of mouse models, and this therapeutic effect was further enhanced by injection of PLX3397, a CSF1R inhibitor that reprograms macrophages.126