The Lmdd-MPFG (LM) vaccine activates the NF-κB pathway in TAMs through the Toll-like receptor (TLR)2-MyD88 pathways, and recruits p62 to activate the autophagy pathway.179,180 The overall effect of LM skews the TAMs from the M2-like state into the M1-like state.181 Most importantly, this approach skewed the TME cytokine profile to anti-tumor profile, and this change restored the T cell reactivity to the anti-PD-1 blockade.180. The gene discussed is NFKB1; the disease is neoplasm.