Additionally, specific RNA-binding proteins (YTHDF1/2/3, IGF2BP1/2/3, eIF3, HNRNPA2B1, etc.), also known as “readers”, can bind to the m6A motif to influence RNA function, thus conferring specific phenotypic outcomes.17,18 Accumulating evidence has demonstrated the m6A modification is associated with various biological processes, including stem cell differentiation, tissue development, and tumor progression. This evidence concerns the gene YTHDF1 and neoplasm.