YTHDF1 and hepatocellular carcinoma: 3-MA treatment reversed the enhanced cell proliferation, migration, and invasion of YTHDF1-overexpressing cells under hypoxia (Supplementary Figs. S5a, b, d, j, and l and S6a, b, d, f, and h), indicating that YTHDF1 could promote malignancy of HCC cells under hypoxia via autophagy activation.