METTL14 and hepatocellular carcinoma: For example, the m6A methyltransferase METTL14 inhibits tumorigenesis in colorectal cancer, bladder cancer, and HCC.19,25,26 However, METTL14 also plays an oncogenic role by regulating the expression of its mRNA targets (e.g., MYB and MYC) via m6A modification in leukemogenesis.27 Owing to recognition by diverse m6A readers, mRNA transcripts with m6A modifications are subjected to different fates.