These results concurred with the reported oncogenic role of YTHDF1 in gastric cancer, ovarian cancer, Merkel cell carcinoma, melanoma, and non-small cell lung cancer.28,34–37 PDX models have been successfully utilized to investigate human malignancies for preclinical therapeutics.38,39 Our experiments with HCC PDX indicated that targeting YTHDF1 might prove to be a promising strategy for HCC treatment. Here, YTHDF1 is linked to Merkel cell skin cancer.