Besides the tumor-promoting effects of YTHDF1 in vitro, we also investigated this effect in YTHDF1flox/flox mice using a conditional knockout strategy to edit the YTHDF1 gene, as shown in Supplementary Fig. S7a, and an N-nitrosodiethylamine (DEN)-induced HCC model (Fig. 4a). The gene discussed is YTHDF1; the disease is hepatocellular carcinoma.