YTHDF1 and hepatocellular carcinoma: However, autophagy was clearly activated and affected to a greater extent by changes in YTHDF1 expression under hypoxia (Fig. 3d, g, j, m-o and Supplementary Fig. S4c, f, i, l–n), which implied that YTHDF1 played a more important role in promoting HCC autophagy under hypoxia than under normoxia.