In hepatocellular carcinoma, hypoxia induces the expression of ENTPD2 on cancer cells; This increases extracellular 5'-AMP, and in turn, promotes MDSC maintenance by preventing its differentiation [15]; moreover, studies have shown that ENTPD2 is of great significance in the diagnosis, monitoring and prognosis of LUAD [16]. This evidence concerns the gene ENTPD2 and cancer.