Indeed, the umbrella term monoclonal gammopathy of renal significance has recently been suggested to cover all M-protein-mediated kidney disorders that fail to meet the diagnostic criteria for multiple myeloma or any other B-cell malignancy.13 18 43 Other organ-specific terms continue to emerge, and with a view to improving recognition of these complex disorders which clearly pose significant diagnostic and treatment challenges, the overarching term monoclonal gammopathy of clinical significance has also been suggested.18 Here, MYOM2 is linked to AL amyloidosis.