MYOM2 and plasma cell myeloma: Indeed, the umbrella term monoclonal gammopathy of renal significance has recently been suggested to cover all M-protein-mediated kidney disorders that fail to meet the diagnostic criteria for multiple myeloma or any other B-cell malignancy.13 18 43 Other organ-specific terms continue to emerge, and with a view to improving recognition of these complex disorders which clearly pose significant diagnostic and treatment challenges, the overarching term monoclonal gammopathy of clinical significance has also been suggested.18