TARDBP and amyotrophic lateral sclerosis: Using this setup, we have previously reported about deficient mitochondrial and lysosomal organelle trafficking in iPSC-derived spinal motor neurons from ALS patients bearing mutant fused in sarcoma (FUS) (Naumann et al, 2018) and TDP43 (Kreiter et al, 2018), two frequent genetic causes of ALS.