Using this setup, we have previously reported about deficient mitochondrial and lysosomal organelle trafficking in iPSC-derived spinal motor neurons from ALS patients bearing mutant fused in sarcoma (FUS) (Naumann et al, 2018) and TDP43 (Kreiter et al, 2018), two frequent genetic causes of ALS. This evidence concerns the gene FUS and amyotrophic lateral sclerosis.