The main rule identified in our study, that is, neuronal death induced by mutant huntingtin may be primarily driven by the loss of homeostatic responses, is noticeably relevant to the loss of homeostatic responses such as the activation of autophagy (see, e.g., Atg4b; Figure 3B), which corroborates, on a molecular systems level, the importance of autophagy in HD as previously supported by the role of HTT as a scaffold protein in autophagy (Ochaba et al., 2014; Rui et al., 2015; Croce and Yamamoto, 2019). Here, ATG4B is linked to Huntington disease.