To dissect the nature and evolution of the cell-type-specific molecular responses that may develop in the striatum of the ‘allelic series’ Hdh mice (a set of HD models that all possess a humanized exon one knock-in Htt allele and differ only by a series of increasing CAG repeat lengths; Wheeler et al., 1999; Menalled et al., 2003; Heikkinen et al., 2012; Menalled et al., 2012; Langfelder et al., 2016; Franich et al., 2019), we designed Geomic, a workflow in which the shape deformation principle is applied to the analysis of complex genomic data (Figure 1, see also Materials and methods). The gene discussed is HTT; the disease is Huntington disease.