We applied this approach to the analysis of the cell-type-specific and temporal features of molecular responses in mouse models of Huntington's disease (HD), an ND that is caused by CAG repeat expansion in the huntingtin gene (HTT; Zuccato et al., 2010) and that is characterized by large changes to gene expression in the striatum and cortex (Moumné et al., 2013). This evidence concerns the gene HTT and Huntington disease.