The gene Foxo1 (down-regulation assigned to Drd2-MSNs: compensatory response that is increased then maintained) belongs to the Forkhead family of transcriptions factors, a class of stress response factors that is associated with modulation of neuronal dysfunction in NDs, including HD, as shown in C. elegans (daf-16/FOXO) and cellular (Foxo3) models (Parker et al., 2005; Tourette et al., 2014). This evidence concerns the gene DRD2 and Huntington disease.