MSH3 and Huntington disease: We also identified six genes that are implicated in a molecular response in the zQ175DN mice and that have a human ortholog harboring an HD onset modifier with a genomic significance comprised between 10−6 and 10−4, including Golga4, a golgin, Tcerg1, a transcription elongation regulator (also known as CA150), Farp2, an ARH/RhoGEF gene also associated with Parkinson's disease and Bag1, a chaperone regulator important for the proteasome and lysosome in group I, extending to Msh3, a mismatch repair protein, and Hdlbp, a high-density lipoprotein binding protein, in group II (Figure 4C).