Finally, the transcription and stress-response factor Nfe2l3 (up-regulation assigned to Drd1-MSNs and astrocytes: compensatory response that increased then maintained) might be relevant to HD in that this protein acts via multiple mechanisms (e.g., UPR, protein quality control of the ER, inflammation, cell division) that are associated with HD pathogenesis (Chowdhury et al., 2017). The gene discussed is DRD1; the disease is Huntington disease.