Accumulating evidence ranging from molecular mechanisms to biochemical (physiological) and clinical data suggests that vitamin D deficiency contributes to hypertension and proposes an antihypertensive effect of this vitamin, through vasculo- and renoprotective effects, suppression of the renin-angiotensin-aldosterone system, and effects on calcium homeostasis, among others [120]. The gene discussed is REN; the disease is vitamin D deficiency.