E2F3 and nonpapillary renal cell carcinoma: According to the results of overlapping the prediction of three different databases (miRDIP: http://ophid.utoronto.ca/mirDIP/; TargetScan: http://www.targetscan.org/vert_72/; TarBase: https://www.tarbase.com/), 21 potential miR-15a-5p target genes were found, among which E2F3 was the most likely gene targeted miR-15a-5p in ccRCC (Supplementary Fig. 2).