Since the PI3K pathway is also commonly dysregulated in breast cancer [3] and given the existence of an extensive crosstalk between the ERK/MAPK and PI3K pathways in addition to their prominent role in a large plethora of cancer-associated processes [6], we sought to extend our investigations and assess the involvement of the PI3K pathway in L-plastin Ser5 phosphorylation in breast cancer cells. Here, PIK3CA is linked to cancer.