HIF1A and neoplasm: Further, progranulin tumor expression was significantly linked to histological grade (p< 0.001), where patients with high-grade tumors showed high progranulin expression, in addition to Ki-67 (p=0.001) and the hypoxic marker hypoxia-inducible factor 1-alpha (HIF1α) (p=0.002) (see Additional file 5: Table S1).