GRN and neoplasm: In support for an important additive function for sortilin in the progranulin high patient group, high tumor tissue expression of sortilin was significantly linked to BCSS (HR=3.013, 95% CI: 1.219–7.448, p=0.017) together with lymph node (LN) positivity (HR=3.854, 95% CI: 1.666–8.919, p=0.002) and tumor size (HR=1.089, 95% CI: 1.037–1.143, p=0.001) (C-index: 0.701) (see Additional file 5: Table S4).