Although S. maltophilia isolates naturally produce two β-lactamases (L1 and L2), the inhibitory activities of CAZ and ATM against L2-producing S. maltophilia isolates might theoretically be re-established by AVI combination; furthermore, given the potential bactericidal activity of ATM against L1-producing S. maltophilia isolates, ATM-AVI might be useful to treat infections with both L1- and L2-producers. Here, ATM is linked to infection.