NFKB1 and colorectal carcinoma: H2S-releasing compounds exhibit potent anticancer effects through inhibition of the proliferation and/or inducing apoptosis in several types of cancer cell, including CRC, but the mechanism that is involved remains unknown and could be related to H2S inhibiting nuclear factor-κB (NF-κB) signaling and increasing intracellular Ca2+ concentration, which leads to cell cycle arrest [102,103].