NFKB1 and colorectal carcinoma: Furthermore, UDCA up-regulates colonic major histocompatibility(MHC) expression, which enhances the immune surveillance of tumors [53], suppresses cox-2 in CRC [47], and inhibits NF-kappaB (NF-κB) activated IL-1 and deoxycholic acid induced Aβ and AP-1 in human CRC cells [54].