POLD1 and mandibuloacral dysplasia with type A lipodystrophy: MDPL and Mandibuloacral Dysplasia type A (MADA; OMIM #248370) or Hutchinson-Gilford progeria syndrome (HGPS; OMIM #176670) show overlapping clinical manifestations and belong to similar groups of syndromes characterized by premature aging and inheritable nuclear envelope and/or DNA repair defects.