PLAUR and systemic sclerosis: Abnormalities in the uPA or uPAR systems in endothelial cells have been implicated in vascular complications related to SSc [39–41], and suPAR has been described as a marker of cardiovascular risk and mortality [26, 42], We did not find a difference in log(suPAR) levels in SSc patients with and without vascular manifestations (pulmonary hypertension, telangiectasias, past or present digital ulcers).