Our results found that anemia, lymphopenia, esinophilia, elevated CRP, LDH, AST, serum albumin, and creatinine levels, and low PI were significantly higher in COVID-19 malignant patients compared to COVID-19 non malignant patients, furthermore, low platelet count and high D-dimer were encountered in malignant group more than non-malignant group. The gene discussed is ALB; the disease is lymphopenia.