Undoubtedly, immune-mediated inflammation plays an important role in the pathogenesis of COVID-19 with progressive reduction in lymphocytic count and elevation of neutrophilic count, immune disturbance in covid-19 starts early in infection with progressive reduction in B cells, CD8+, CD4+ T cells, NK cells which precedes radiologic evidence of the disease [23, 30]. The gene discussed is CD8A; the disease is infection.