Results suggested that the levels of pro-apoptotic protein Bax, Bak, Bad, cleaved Caspase-9 and cleaved Caspase-3 were decreased, while that of the anti-apoptotic protein Bcl-2 was increased, in let-7e mimic–transfected HCC cells (Figure 6C, 6D). The gene discussed is BAD; the disease is hepatocellular carcinoma.