Interestingly, our data indicate that simultaneous administration of IL-2 and IL-4 in vivo suppressed the severity of not only IL-17-dependent EAE (Komiyama et al., 2006), but also several models of murine asthma in both Th1 and Th2-skewed backgrounds (Gueders et al., 2009). This evidence concerns the gene IL17A and asthma.