Yet, IL-4 is also a key differentiating factor for wound healing macrophages (Gordon, 2003), which is essential for tissue repair, and is known to oppose IL-17-mediated inflammatory diseases like psoriasis and experimental autoimmune encephalomyelitis (EAE) (Vogelgesang et al., 2010; Weigert et al., 2008). This evidence concerns the gene IL4 and experimental autoimmune encephalomyelitis.