Previous studies also demonstrated that some viruses such as Japanese encephalitis virus [31], porcine circovirus type 2 [32], Middle East respiratory syndrome coronavirus [33] and influenza virus [34–37] could hijack KPNA3/4 to competitively block the interaction of KPNA3/4 with their cargos, and then to restrict their function to establish infection or evade the host antiviral response. The gene discussed is KPNA3; the disease is infection.