The proportion of patients with stage III‐IV HCC, according to the tumour‐node‐metastasis (TNM) staging system, in LIHC‐cluster B was higher (χ2 = 11.35, P < .01) than that in LIHC‐cluster A, and the alfa‐fetoprotein (AFP) level in LIHC‐cluster B was higher than that in LIHC‐cluster A (χ2 = 4.44, P < .05). Here, AFP is linked to hepatocellular carcinoma.