In this work, we aimed to evaluate the predictive values of: (1) the known markers of sFlt‐1 and PlGF, and (2) PAPP‐A2, GlyFn, TM, tissue plasminogen activator inhibitor complex (tPAI‐C), complement factors C1q, B, and H, and renal function markers including UA, BUN, Cre, and Cysc, in a prospective study with Chinese pregnant women who were suspected to develop preeclampsia. This evidence concerns the gene PAPPA2 and preeclampsia.