In uteroplacental thrombosis, which is one of the major mechanisms of preeclampsia, several thrombotic and fibrinolytic factors including circulating soluble thrombomodulin (TM) and tissue plasminogen activator (tPA) were found to be elevated in PE and correlated with the severity of proteinuria.14, 15. The gene discussed is PLAT; the disease is Venous thrombosis.