In present study, we evaluated the predictive values of the following serum biomarkers in a prospective study with the women suspected to develop preeclampsia (PE): soluble fms‐like tyrosine kinase 1 (sFlt‐1), placental growth factor (PlGF), pregnancy‐associated plasma protein‐A2 (PAPP‐A2), glycosylated fibronectin (GlyFn), thrombomodulin (TM), tissue plasminogen activator inhibitor complex (tPAI‐C), uric acid (UA), blood urea nitrogen (BUN), creatinine (Cre), and cystatin C (Cysc). This evidence concerns the gene CST3 and preeclampsia.