Indeed, because we observed an increase in PD-1 expression on FcγRIIB+ cells in the tumor, it is interesting to speculate that ligation of FcγRIIB by anti–PD-1 checkpoint inhibitors (28) could be sending an inhibitory signal to antitumor CD8+ T cells, counteracting the efficacy of anti–PD-1 checkpoint blockade. This evidence concerns the gene CD8A and neoplasm.