Our results demonstrate that patients having the same HLA-A type used private TCR repertoires to recognize HTLV-1 Tax11-19 peptide; however, there was a conserved CDR3 motif (PGLAG) in HTLV-1 Tax–specific CTLs across HLA-A*0201+ HAM/TSP patients. This evidence concerns the gene HLA-A and tropical spastic paraparesis.