The three hot spots of nAChR channel research were “subunit and structure of nAChR,” “activation/agonist of nAChR channel,” and “Changes in nAChRs With Alzheimer’s Disease.” The top three research frontiers were “neuropathic pain,” “neuroinflammation,” and “α7 nAChR.” Bibliometric analysis of the literature on the nAChR channels contributes researchers to identify cooperations, find research hotspots, and predict the frontiers of nAChR channel research. This evidence concerns the gene CHRNA7 and early-onset autosomal dominant Alzheimer disease.