The 16p11.2 distal CNV (BP2‐BP3, 28.7 to 28.9 Mb; hg18 genome assembly) predisposes carriers to psychiatric conditions including ASD and SCZ and had been associated with macro‐ and microcephaly in deletion and duplication carriers, respectively (Loviglio et al., 2016). This evidence concerns the gene IGFBP2 and microcephaly.