In the human body, mutations of the eukaryotic translation initiation factor 2α kinase 3 (EIF2AK3) gene (encoding PERK) can cause a rare autosomal recessive genetic disease: Wolcott‐Rallison syndrome (WRS), which features early‐onset type I diabetes, skeletal dysplasia and osteoporosis, this phenomenon indicates that PERK has a potential regulatory effect on the skeletal system.42 This evidence concerns the gene EIF2AK3 and Wolcott-Rallison syndrome.