The autoimmune nature of the molecular changes observed in PBC and in PV [11,12], the evidence that autoimmunity is responsible for the direct participation of autoreactive MNRR1 in breast carcinogenesis [1], and the report of consistent mitochondrial autoreactivity detected by IFA in BC sera [9], suggested that a comprehensive survey of mitochondrial autoreactivity in BC could reveal a wealth of diagnostic and prognostic biomarkers. This evidence concerns the gene CHCHD2 and Autoimmunity.