HIF1A and triple-negative breast carcinoma: In this recent finding, Tanaka et al. [60], was able to demonstrate that ERO1α up-regulates PD-L1 surface expression not only through oxidative folding, but also unexpectedly up-regulated PD-L1 mRNA expression through augmentation of hypoxia inducible factor-1alpha (HIF-1α) in human triple negative breast cancer cell lines.