- Key binding partner of DISC-1- ↓ Nde1 impairs process formation in oligodendrocytes and disrupts neuron–oligodendrocyte contact formation and myelination. Oligodendrocytes dysfunction and myelin abnormalities can lead to cognitive deficits and are reported in neuropsychiatric diseases including schizophrenia. The gene discussed is NDE1; the disease is Cognitive impairment.