In this study, we assessed in both neocortex and hippocampus of Ndel1 CKO mice the levels and/or activity of a dozen proteins linked to Ndel1 functions, and potentially to Ndel1 CKO phenotypes, epilepsy and/or schizophrenia (Nde1, Lis1, GFAP, GluR1, Tau-PHF-1, Cdk5/p35, CaMKIIα, Akt, GSK3β, PKA, DISC-1, and TDP-43; see Table 1 for details). The gene discussed is NDE1; the disease is epilepsy.