MAPT and epilepsy: 2011), and MTs depolymerization exacerbates the severity and prolongs the duration of SRS in two rat models of adult epilepsy (i.e., pentylenetetrazol [PTZ]-kindling and pilocarpine, these combined results suggest that Tau hyperphosphorylation may contribute to epileptogenesis and spatial learning and memory deficits in the Ndel1 CKO mice; Kiroski et al.