On the other hand, the higher-affinity binders, rEgA, and rEgH9, exhibiting relatively low off-rates and almost the same on-rates as rAC1 might be preferentially deployed around the tumor vascular niche to form stable repebody-EGFR binary complexes, resulting in poor interstitial transport and limited tumor localization. The gene discussed is RAC1; the disease is neoplasm.