For instance, AhR knockdown in HepG2 cells was shown to decrease cell proliferation due to downregulation of cell-cycle-related genes (Abdelrahim et al., 2003), whereas agonism of AhR by TCDD was shown to suppress cell proliferation of OVCAR-3, a human ovarian cancer cell line (Li et al., 2014). Here, AHR is linked to ovarian carcinoma.