IL25 and parasitic infectious disease: IL-25 also plays a role in immune homeostasis and defense against infection; in this respect, von Moltke et al. [19] demonstrated in murine models that constitutive secretion of IL-25 from intestinal tuft cells is important for a circuit of ILC2 and epithelial cells, which is amplified in the case of parasite infection contributing to defense against the pathogen [19].