CASR and neoplasm: This finding would appear to be in conflict with the oncogenic role of this specific miR that has been consistently reported to be overexpressed and to downregulate the CaSR gene in various tumors.(33, 34) However, it seems that the tissue expression of miRs in sPAs follows an expression pattern that can promote tumorigenesis, and at the same time exert an autoregulatory tumor suppression mechanism.