Significantly, HBx/c-Myc bi-transgenic mice expressing c-Myc under the control of the woodchuck hepatitis virus (WHV) regulatory elements, exhibit accelerated formation of liver tumors[34], demonstrating the cofactor role of HBx in HBV-mediated hepatocarcinogenesis; and (4) infection by distinct HBV genotypes, associated with poor prognosis HBV-related liver cancer[35]. The gene discussed is MYC; the disease is infection.