MMP3, MMP13, and MT1-MMP are potent regulators of electron cryomicroscopy (ECM) remodeling, thereby facilitating the spreading of tumor cells from primary sites, while MMP2 and MMP9 are capable of inducing angiogenesis and the formation of pre-metastasis niches, thus further promoting tumor metastasis.35 Here, MMP13 is linked to neoplasm.