Among the family of MMPs, MMP2 plays a crucial role for the remodeling of basement membrane via degrading collagen I, IV, V, plasminogen, and laminin-5, hence promoting angiogenesis and paving a way for tumor cell migration as seen in melanoma and lung carcinoma.13, 14, 15, 16 MMP2 also induces angiogenesis via mediating the expression of important angiogenic factors like vascular endothelial growth factor (VEGF) and MMP9.17 Here, VEGFA is linked to melanoma.