FSCN1 and Familial prostate cancer: ,55,120,129 Downregulation of FSCN1 expression in prostate cancer cells DU14510 or renal cancer cells 786-O120 was shown to suppress tumor metastases in nude mice, whereas the overexpression of FSCN1 in osteosarcoma SaOS-2 cells enhanced lung metastasis in severe combined immunodeficiency (SCID) mice.