FSCN1 and cancer: ,5,7,10,12,121 As a therapeutic target, FSCN1 has several advantages: (1) it is important for tumor progression and promotes tumor cell migration, invasion, and metastasis (refer to Tables 1 and 2); (2) it is upregulated in many human cancers and has been correlated with clinically aggressive phenotypes and poor prognosis (refer to Table 3); and (3) FSCN1 knockout mice are viable,61,276 suggesting that targeting FSCN1 would have limited side effects in patients.