Aslan et al. (28) reported MDA levels were found significantly higher whilst the GSH-Px, CAT, and SOD activities were significantly lower in lambs with Pestivirus than that of controls and trinitrobenzenesulfonic acid (TNBS)-induced colitis in mice, which was widely used as Crohn's disease (CD) models, showed the same result—that the enzyme activity of GSH-Px was significantly decreased, while MDA was significantly increased in the TNBS group compared with the blank group (29). Here, SOD1 is linked to Cowden disease.