Isatin-triazole hydrazones (V, Figure 5), were also described as anticancer agents as well as potent inhibitors of Microtubule affinity-regulating kinase 4 (MARK4), known to induce proliferation and migration of cells in breast cancer, also associated with hepatocellular cancer (Naz et al., 2013). This evidence concerns the gene MARK4 and breast carcinoma.