Few researches reported EGR4 in malignant tumors; only some articles reported that EGR4 might promote NSCLC (He et al., 2019), small cell lung cancer (SCLC) (Matsuo et al., 2014), and cholangiocarcinoma (CHOL) to develop (Gong et al., 2020). The gene discussed is EGR4; the disease is cholangiocarcinoma.