CKAP4 and intrahepatic cholangiocarcinoma: However, there are opposing reports about CKAP4 as an anticancer protein in various kinds of tumors, such as hepatocellular carcinoma (HCC), intrahepatic cholangiocellular carcinoma (ICC), and glioma (Li et al., 2013; Li et al., 2014b; Lu et al., 2018).