The formation of the xenograft tumors derived from CKAP4-depleted cells, including lung cancer cells (Kimura et al., 2016), pancreatic cancer cell (Kimura et al., 2016), and ESCC cells (Shinno et al., 2018), was much less than that of control tumors. This evidence concerns the gene CKAP4 and familial pancreatic carcinoma.