The sensitivity and specificity for HCC diagnosis of CKAP4 alone had no advantage compared with AFP, but combined CKAP4 and AFP showed a better diagnostic accuracy (sensitivity = 0.8, specificity = 0.963), even in early HCC (sensitivity = 0.762, specificity = 0.963), which was similar to our results (Wang et al., 2019) (Table 3). The gene discussed is AFP; the disease is hepatocellular carcinoma.