Taken together, the evidence supporting exosomal carriage of functional and transferable integrin proteins, such as those belonging to the αV family (Fedele et al., 2015; Singh et al., 2016; Krishn et al., 2019), and the identification of integrins as signaling receptors (Kim H. et al., 2018) propose irisin-exosome interactions as potential players in niche regulation especially in cancer metastasis (Figures 1–3). The gene discussed is FNDC5; the disease is cancer.