Kang et al. (2018) described a variable response to hypoxia on a set of UCB-MSCs derived from 7 cords on a panel of 4 genes (ANGPTL4, ADM, CDON, and GLUT3); better responders were associated with higher angiogenic potency in vitro, and showed better performance in vivo with 2 cords when challenged in a model of limb ischemia. Here, CDON is linked to limb ischemia.