In particular, the hypermethylation of CGIs in promoters of relevant genes (p16/CDKN2A, MLH1, MGMT, APC, and TIMP3, among others) is associated with CRC pathogenesis (Gonzalez-Zulueta et al., 1995; Hiltunen et al., 1997; Kane et al., 1997; Esteller et al., 1999; Lee et al., 2004). Here, CDKN2A is linked to colorectal carcinoma.