Comparison of transcriptomes of GBM cells treated with HMGB1 and PBS showed that the expression of NEAT1, a lncRNA reportedly playing important roles in GSCs (Gong et al., 2016; Yang et al., 2017; Lulli et al., 2020), was significantly upregulated (Figure 7A). The gene discussed is HMGB1; the disease is glioblastoma.