In addition, in gene expression profiling of GBM reported in TCGA and CGGA databases, higher levels of TLR2 correlated with a decrease in median survival of GBM patients and TLR2 was positively correlated with the expression of CD133, SOX2 and OCT4 (Supplementary Figures 4A,B), consistent with previous studies (Chen et al., 2019). This evidence concerns the gene SOX2 and glioblastoma.