Moreover, circHIPK3 sponged the tumor-suppressive miR-124 leading to an increased expression of miR-124 targets, including rho-associated protein kinase 1 (ROCK1) and CDK6, thereby showing the potential of circHIPK3 as a potential diagnostic marker and therapeutic target in GBC (Kai et al., 2018). This evidence concerns the gene ROCK1 and neoplasm.