Under conditions of elevated protein methyltransferase 1 (PRMT1), as the case in cancer or aging (Blanc and Richard, 2017), UCP2 interacts with PRMT1-methylated MICU1 and re-establishes its Ca2+ sensitivity resulting in a normalization of mitochondrial Ca2+ uptake (Madreiter-Sokolowski et al., 2016a). Here, UCP2 is linked to cancer.