A study using triple-negative breast cancer xenografts demonstrated that downregulation of MCU hampers cell motility, invasiveness, and tumor progression and revealed a positive correlation between MCU expression and hypoxia-inducible factor-1α (HIF-1α), hinting to an MCU-associated regulation of cancer progression via HIF-1α (Tosatto et al., 2016). The gene discussed is HIF1A; the disease is cancer.