CASP3 and cancer: Notably, several ER stress markers, including GRP78, IRE1A, PERK, BAX, and CASP3 were also found to be upregulated in breast invasive cancer (Figure 4F), prostate adenocarcinoma (Figure 4G) and cervical squamous cell carcinoma (Figure 4H), a potential hint that ER stress in cancer cells might induce alterations in the mitochondrial-ER interplay and the expression of UCP2 in cancer.