EZH2 and head and neck squamous cell carcinoma: Moreover, a study based on a xenograft tumor model revealed that targeting the enhancer of zeste homolog 2 (EZH2), known as a negative prognostic factor in most human cancers, regulates growth, and apoptosis of head and neck squamous cell carcinoma via MICU1, required to maintain stability of mitochondrial membrane potential (Zhou et al., 2015).