1 Meflin is expressed in CAFs originate from pancreatic stellate cells2 Meflin positive CAFs showed decreased a-SMA expression and stromal collagen regulating3 Meflin negative CAFs showed more aggressive pro-tumorigenic functions4 Meflin knockout mice showed a poorly differentiated tumor with more a-SMA + CAFs compared to Meflin wild type mice. The gene discussed is ISLR; the disease is neoplasm.