1 In RAMP3-/- mice, spleen injection of PAN02 murine pancreatic cancer cells showed reduced liver metastasis.2 RAMP3-/- mice metastatic tumor showed decreased podoplanin positive or α-SMA positive CAFs.3 Primary RAMP3-/- CAFs inhibited proliferation, migration, and metastasis in co-cultures with PAN02 murine pancreatic cancer cells. This evidence concerns the gene PDPN and metastatic neoplasm.